Azathioprine
Azathioprine
ATC Code: L04AX01
Warning
Thiopurines Linked to Increased Lymphoma Risk in Patients with Inflammatory Bowel Disorders :
Patients using thiopurines to manage inflammatory bowel disease face increased risk for lymphoproliferative disorders, according to an observational study published online in Lancet.
Researchers in France followed some 19,500 patients with inflammatory bowel disease (Crohn disease, ulcerative colitis, or unclassified disease) for about 3 years.
During follow-up, lymphoproliferative disorders were diagnosed in 23 patients — 15 thiopurine users, 2 former users, and 6 patients who'd never used thiopurines. In adjusted analyses, lymphoma risk was five times higher among current users than among those who'd never received the drugs.
Evidence
Fair
Reference
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