Dermatophytosis (Plantar-type tinea pedis)
First Line Drugs
- TERBINAFINE (D01AE15)
- TERBINAFINE (D01BA02)
- ERYTHROMYCIN (J01FA01)
terbinafine 1% cream, once daily to bidx 1-2 weeks $13.50/30 g
or terbinafine 250 mg, once daily x 2 weeks $24.91/week
or itraconazole 200 mg, once daily x 1 week $49.00/week
Terbinafine and itraconazole were more effective than no treatment, and terbinafine appeared to give a significantly better cure rate than griseofulvin. In addition, terbinafine may require a shorter treatment period (2 weeks), which is preferable for maximising patient compliance. No significant difference was detected between terbinafine and itraconazole, fluconazole and itraconazole, fluconazole and ketoconazole, or between griseofulvin and ketoconazole, although the trials were generally small. All drugs reported adverse effects, with gastrointestinal effects being most commonly reported.
Bell-Syer SEM et al. Oral treatments for fungal infections of the skin of the foot. Cochrane Reviews, 2012, Issue 10. Article No. CD003584.DOI: 10.1002/14651858.CD003584.pub2.
This review contains 15 studies involving 1438 participants.