Erythromycin and Atorvastatin
Affecting DrugsJ01FA01  Erythromycin
Affected DrugsC10AA05  Atorvastatin
When lovastatin and some macrolide antibiotics (erythromycin) have been used concomitantly in severely ill patients, severe myopathy and rhabdomyolysis have resulted. The mechanism appears to be inhibition of lovastatin metabolism by the macrolide. Patients should be instructed to report symptoms of muscle pain, weakness, or tenderness. If symptoms occur, creatine kinase should be measured. If creatine kinase is elevated, the drugs should be discontinued. A similar reaction may occur with other HMG-CoA reductase inhibitors.